拜托大虾们解答一下这两个问题

sweetnini

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这是我期末考试可能会考到的一道题目，拜托大虾们帮我解释一下该怎么做：

    To resolve overlapping resonances in a 2D spectrum of a protein acquired in 24 hours at 500MHz, a spectroscopist decided to measure a 5D spectrum using a 600MHz spectrometer. how long does he need to accumulate the 5D spectrum in order to reach the same signal-to-noise ratio as in the original 2D spectrum?

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2. a 3D HNCA spectrum of a membrane protein in 500 mM NaCl aqueous buffer, using a spectrometer of 500 MHz with maximal signal-to-noise ratio S/N=2:1, has been obtained after 24 hours of data acquisition.
which change in experimental setup would provide the lagest increase in S/N?
a) Repeating the experiment in the same time (24 hours) using a spectrometer operating at 600MHz.
OR
b) Repeating the same experiment for the next 24 hours and summing two 1H spectra together

 

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    真郁闷死了！碰上个印度教授，英语口音重得很，完全听不懂他讲什么！只有上专业论坛来求助专家了！拜托大家给我这个菜鸟好好解释一下！ 谢谢了！
 

sweetnini

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我们只学了非常浅显的一些理论，那个教授没有给我们任何公式可以计算这个，但是我想这个题目不应该很难计算。可是我花了一天时间，网上资料都翻烂了也没找出个头绪。拜托大家给我指点一二。

heross

提高信噪比可以延长采样时间，提高采样次数